Iron is an essential element required in many important biologicalfunctions, butexcess iron can be toxic. An imbalancein iron uptake and efflux is known tocause several disorders. Iron imbalance often promotes inflammatory conditions by inducing the expression of cytokines like IL6, IL1B, TNF alpha, and TLR 4.

My work is focused on Iron metabolism and inflammation due to irondyshomeostasis. Medicinal plants have different phytoconstituents like steroids, flavonoids, alkaloids, glycosides, phenolics, polysaccharides, and terpenoids are beneficial due to the terpenoids are beneficial due to their properties like anti-inflammatory andimmunomodulatory activity. Crinum species are used in traditional medicinalsystem against cough and asthma because of their anti-inflammatory andimmunomodulatory activity.

Therefore, I aminterested in studying the effect ofCrinum species against inflammation caused due to Iron dyshomeostasis.

1. Padmaja Shete, Niraj Ghatpande, MokshadaEvameshwar Varma, PranavVijay Joshi, KomalRavindra Suryavanshi, Ashwini Misar, SachinJadhav, Priti Apte, Prasad Kulkarni.Chronic dietary iron overload affects hepatic iron metabolism andcognitive behaviour in Wistar rats. Journal of Trace Elements inMedicine and Biology 84, 127422, 2024https://doi.org/10.1016/j.jtemb.2024.127422
2. Nissi Sharon, Vinod G. Ugale, Pannala Padmaja, Deepak Lokwani,Chandradeep Salunkhe, Padmaja Shete, Pedavenkatagari NarayanaReddy, Prasad P. KulkarniDevelopment of novel9H‐carbazole‐4H‐chromene hybrids as dual cholinesteraseinhibitors for the treatment of Alzheimer’s disease. MolecularDiversity, 2024https://doi.org/10.1007/s11030-024-10859-z
3. Mokshada Varma, Vinod Ugale, Javeria Shaukat, Michael Hollmann,Padmaja Shete, Bhupendra Shravage, Sakharam Tayade, AvinashKumbhar, Ray Butcher, Vinod Jani, Uddhavesh Sonavane, RajendraJoshi, Deepak Lokwani, Prasad Kulkarni. Novel alkyl-substituted 4-methoxy benzaldehyde thiosemicarbazones: Multi-target directedligands for the treatment of Alzheimer’s disease. European Journal ofPharmacology, 957, 176028, 2023https://doi.org/10.1016/j.ejphar.2023.176028