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Name : Dr. Virendra Gajbhiye
Designation : Scientist – E
Brief Background :
Dr. Virendra Gajbhiye has been working in the field of nanomedicine forthe last 15 years. He did his bachelor’s and master’s degrees in Pharmacy. He has a doctoral degree (Ph.D.) in Pharmaceutical Science. He gained postdoctoral research experience at Wisconsin Institute for Discovery, Dept. of Biomedical Engineering, University of Wisconsin, Madison (WI, USA) and Dept. of Biomedical Engineering, Oregon Health and Science University, Portland (OR, USA).
Since December 2013, he is working as a Scientist in Nanomedicine at Agharkar Research Institute, Pune, India. He has worked extensively with polymeric nanoparticles specially dendrimers and mesoporous silica nanoparticles. Currently, his research interests lie primarily in the development of nanotechnology-based gene therapy for the treatment of various cancers and cardiac repair as well as regeneration using Nucleic acid therapy.
Contact Details :
+91-20-25325140
- Bachelor of Pharmacy (2004) fromRajiv Gandhi Technical University, Bhopal (MP) Pharmacy
- Master of Pharmacy(2007; Honors) from Dr. H. S. Gour Central University, Sagar (MP)
- Ph. D. in Pharmaceutical Sciences (2011) from Dr. H. S. Gour Central University, Sagar(MP)
- Postdoctoral Research Associate(2012) Wisconsin Institute for Discovery, Dept. of Biomedical Engineering, University of Wisconsin, Madison (WI, USA)
- Postdoctoral Research Associate(2013) Dept. of Biomedical Engineering, Oregon Health and Science University, Portland (OR, USA)
Nanomedicine, Targeted drug/siRNA/miRNA/SSO delivery, Nano-immunosensors, Tissue engineering, Regenerative nanomedicine, Biomedical application of dendrimers & mesoporous silica nanoparticles, Biomaterials, Unimolecular micelles and imaging, Multifunctional polymeric nanoparticles, Nanotheranostics, Nucleic acid therapy, Gene therapy
Papers published in refereed journals
- Deshmukh , N. S. Pathan , N. Haldar , S. Nalawade , M. Narwade , K. R. Gajbhiye, V. Gajbhiye. (2025) Exploring intranasal drug delivery via nanocarriers: A promising glioblastoma therapy. Colloids and Surfaces B: Biointerfaces, 245: 114285
- Shaikh, A., P. Kesharwani, and V. Gajbhiye, “Dendrimer as a momentous tool in tissue engineering and regenerative medicine,” J. Control. Release, vol. 346, no. January, pp. 328–354, 2022, doi: 10.1016/j.jconrel.2022.04.008. IF – 11.467
- Narwade, A. Shaikh, K. R. Gajbhiye, P. Kesharwani, and V. Gajbhiye, “Advanced cancer targeting using aptamer functionalized nanocarriers for site-specific cargo delivery,” Biomater. Res., vol. 27, no. 1, p. 42, May 2023, doi: 10.1186/s40824-023-00365-y. IF – 11.3
- Salve, R., Haldar, N., Shaikh, A., Samanta, R., Sengar, D., Patra, S., et al. (2024). MUC1 aptamer-tethered H40-TEPA-PEG nanoconjugates for targeted siRNA-delivery and gene silencing in breast cancer cells. Front. Bioeng. Biotechnol. 12, 1–8. doi: 10.3389/fbioe.2024.1383495. IF – 4.3
- Salve, R., Kumar, P., Chaudhari, B. P., and Gajbhiye, V. (2023). Aptamer tethered bio-responsive mesoporous silica nanoparticles for efficient targeted delivery of paclitaxel to treat ovarian cancer cells. J. Pharm. Sci. 000, 1–10. doi: 10.1016/j.xphs.2023.01.011. IF – 3.7
- Gajbhiye, K. R., Salve, R., Narwade, M., Sheikh, A., Kesharwani, P., and Gajbhiye, V. (2023). Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics. Mol. Cancer 22, 1–44. doi: 10.1186/s12943-023-01849-0. IF – 27.7
- Deshmukh, V., Pathan, N.S., Haldar, N., Nalawade, S., Narwade, M., Gajbhiye, K.R. and Gajbhiye, V., 2024. Exploring intranasal drug delivery via nanocarriers: A promising glioblastoma therapy. Colloids and Surfaces B: Biointerfaces, p.114285. IF – 5.4
- Korake, S., Salve, R., Gajbhiye, V. and Pawar, A., 2024. αvβ3 integrin-targeted pH-responsive dendritic nanocarriers for enhanced anti-tumor efficacy of docetaxel against breast cancer. Journal of Drug Delivery Science and Technology, 99, p.105946. IF – 4.5
- Varghese, S., Jisha, M.S., Rajeshkumar, K.C., Gajbhiye, V., Alrefaei, A.F. and Jeewon, R., 2024. Endophytic fungi: A future prospect for breast cancer therapeutics and drug development. Heliyon. IF – 3.4
- Salve, R., Haldar, N., Shaikh, A., Samanta, R., Sengar, D., Patra, S. and Gajbhiye, V., 2024. MUC1 aptamer-tethered H40-TEPA-PEG nanoconjugates for targeted siRNA-delivery and gene silencing in breast cancer cells. Frontiers in Bioengineering and Biotechnology, 12, p.1383495. IF – 4.3
- Varghese, S., Jisha, M.S., Rajeshkumar, K.C., Gajbhiye, V., Haldar, N. and Shaikh, A., 2024. Molecular authentication, metabolite profiling and in silico–in vitro cytotoxicity screening of endophytic Penicillium ramusculum from Withaniasomnifera for breast cancer therapeutics. 3 Biotech, 14(3), p.64. IF – 2.6
- Kumar, P., Salve, R., Paknikar, K.M. and Gajbhiye, V., 2023. Nucleolin aptamer conjugated MSNPs-PLR-PEG multifunctional nanoconstructs for targeted co-delivery of anticancer drug and siRNA to counter drug resistance in TNBC. International Journal of Biological Macromolecules, 229, pp.600-614. IF – 7.7
- Kesharwani, P., Sheikh, A., Abourehab, M.A., Salve, R. and Gajbhiye, V., 2023. A combinatorial delivery of survivin targeted siRNA using cancer selective nanoparticles for triple negative breast cancer therapy. Journal of Drug Delivery Science and Technology, 80, p.104164. IF – 4.5
- Fotooh Abadi, L., Kumar, P., Paknikar, K., Gajbhiye, V. and Kulkarni, S., 2023. Tenofovir-tethered gold nanoparticles as a novel multifunctional long-acting anti-HIV therapy to overcome deficient drug delivery-: an in vivo proof of concept. Journal of Nanobiotechnology, 21(1), p.19. IF – 10.6
- Moudgil, A., Salve, R., Gajbhiye, V. and Chaudhari, B.P., 2023. Challenges and emerging strategies for next generation liposomal based drug delivery: an account of the breast cancer conundrum. Chemistry and Physics of Lipids, 250, p.105258. IF – 3.4
- Kesharwani, P., Fatima, M., Singh, V., Sheikh, A., Almalki, W.H., Gajbhiye, V. and Sahebkar, A., 2022. Itraconazole and difluorinated-curcumin containing chitosan nanoparticle loaded hydrogel for amelioration of onychomycosis. Biomimetics, 7(4), p.206. IF – 3.4
- Tiwari, A., Gajbhiye, V., Jain, A., Verma, A., Shaikh, A., Salve, R. and Jain, S.K., 2022. Hyaluronic acid functionalized liposomes embedded in biodegradable beads for duo drugs delivery to oxaliplatin-resistant colon cancer. Journal of Drug Delivery Science and Technology, 77, p.103891. IF – 4.5
- Shaikh, A., Kesharwani, P. and Gajbhiye, V., 2022. Dendrimer as a momentous tool in tissue engineering and regenerative medicine. Journal of Controlled Release, 346, pp.328-354. IF – 10.5
- More, N.A., Jadhao, N.L., Meshram, R.J., Tambe, P., Salve, R.A., Sabane, J.K., Sawant, S.N., Gajbhiye, V. and Gajbhiye, J.M., 2022. Novel 3-fluoro-4-morpholinoaniline derivatives: Synthesis and assessment of anti-cancer activity in breast cancer cells. Journal of Molecular Structure, 1253, p.132127. IF – 4.0
Book chapters published
- Kadu, M., Salve, R., Gajbhiye, K.R., Choudhary, R.K. and Gajbhiye, V., 2023. Nanoparticle-Mediated Plant Bioactives for Cardiovascular Disease. In Advances in Phytonanotechnology for Treatment of Various Diseases (pp. 199-213). CRC Press.
- Kadu, M., Salve, R., Gajbhiye, K.R., Choudhary, R.K. and Gajbhiye, V., 2023. Historical Perspectives and Advances in Phytonanotechnology. Advances in Phytonanotechnology for Treatment of Various Diseases, pp.1-20.
- Haldar, N., Salve, R., Gajbhiye, K.R. and Gajbhiye, V., 2023. Delivery of Antimalarial Phytochemicals by Nanoscale Approaches. In Advances in Phytonanotechnology for Treatment of Various Diseases (pp. 287-305). CRC Press.
- Gajbhiye, K.R., Dhapte, V., Varma, S., Chaudhari, B.P. and Gajbhiye, V., 2022. Redox-responsive nanomedicine for breast cancer therapy. In Targeted Nanomedicine for Breast Cancer Therapy (pp. 407-439). Academic Press.
- Moudgil, A., Jaiswal, N., Gajbhiye, K.R., Gajbhiye, V., Pawar, A.T. and Chaudhari, B.P., 2022. Hypoxia mediated targeted nanomedicine for breast cancer. In Targeted Nanomedicine for Breast Cancer Therapy (pp. 369-406). Academic Press.
- Sayed-Pathan, N.I., Jadon, R.S., Gajbhiye, K.R. and Gajbhiye, V., 2022. Tailored gold nanoparticles for improved control over drug release. In Stimuli-Responsive Nanocarriers (pp. 283-318). Academic Press.
- Poudel, I., Annaji, M., Arnold, R.D., Gajbhiye, V., Tiwari, A.K. and Babu, R.J., 2022. Vesicular nanocarrier based stimuli-responsive drug delivery systems. In Stimuli-Responsive Nanocarriers (pp. 61-86). Academic Press.
- Kumar, P., Salve, R., Gajbhiye, K.R. and Gajbhiye, V., 2022. An overview of stimuli-responsive nanocarriers: State of the art. Stimuli-Responsive Nanocarriers, pp.1-27.
- Salve, R., Kumar, P., Gajbhiye, K.R., Shende, R.A., Chaudhari, B.P. and Gajbhiye, V., 2022. Mesoporous silica nanoparticles-based stimuli-triggered drug release systems. In Stimuli-Responsive Nanocarriers (pp. 237-264). Academic Press.
- Jadon, R.S., Jadon, P.S., Bhadauria, V., Sharma, V., Bharadwaj, S., Sharma, M., Gajbhiye, K.R. and Gajbhiye, V., 2022. Solid–lipid nanoparticles based vehicles for stimuli inspired delivery of bioactives. In Stimuli-responsive nanocarriers (pp. 265-282). Academic Press.
- Salve, R., Gajbhiye, K.R., Babu, R.J. and Gajbhiye, V., 2022. Carbon nanomaterial-based stimuli-responsive drug delivery strategies. In Stimuli-Responsive Nanocarriers (pp. 367-392). Academic Press.
- Moudgil, A., Shende, R.A., Pawar, A.T., Gajbhiye, K.R., Gajbhiye, V. and Chaudhari, B.P., 2022. Quantum dots based vehicles for controlled drug release in conjunction with bio-imaging. In Stimuli-Responsive Nanocarriers (pp. 197-236). Academic Press.
- Narwade, M., Gajbhiye, V. and Gajbhiye, K.R., 2022. Protein nanocapsules as a smart drug delivery platform. In Stimuli-Responsive Nanocarriers (pp. 393-412). Academic Press.
Books Edited
- Advances in Phytonanotechnology for Treatment of Various Diseases. Prashant Kesharwani, Virendra Gajbhiye. Publication date:- 2023/9/29. Publisher:- CRC Press. ISBN 9781032137469.
- Stimuli-Responsive Nanocarriers: Recent Advances in Tailor-Made Therapeutics. Virendra Gajbhiye, Kavita Gajbhiye, Seungpyo Hong (Eds.) Academic Press. 1st Edition – January 4, 2022. Elsevier. USA. Paperback ISBN: 9780128244562
- Bodas D, Gajbhiye V. 2024. Microfluidics-aided technologies: Platforms for the next generation biological applications. Academic Press. Elsevier
Indian patents granted
- Nanocarrier for delivery of an ensconced payload, method of its preparation, and applications thereof. Patent No 458152; Date of Grant: October 11, 2023 Vandana Ghormade, Virendra Gajbhiye, K. M. Paknikar
- Y Karpe, V Gajbhiye, D Bodas and P Dhakephalkar, Nucleic acid-based test kit to detect viral RNA, DNA, other biomolecules and an assay thereof. Patent Application No. 202121027919. Date of Grant 26-06-2024
Patent Applications
Endophytic Penicillium setosum SVWS1 derived anticancer compound for breast cancer therapeutics. Patent Application No. 202421003897
Ph. D. awarded
Rajesh Salve: Targeted co-delivery of siRNAs for effective therapeutic outcome against metastatic ovarian cancer. Guide: Dr. V. Gajbhiye
Other important information
- Dr. V. Gajbhiye elected as Fellow of Maharashtra Academy of Sciences (MASc). Fellowship No. ELF1196.
- Vocational Excellence Award from Rotary Club, Pune for contributions to research in Nanotechnology and its applications in healthcare.
- Control Release Society (CRS, Indian Chapter) 2nd Best Poster Award 2023 with cash price of INR 25,000.
- Dr. Virendra Gajbhiye appears in the list of Top 2% Scientists list released by Stanford University. His inclusion is for the fourth consecutive year.
- V. Gajbhiye: Keynote talk entitled “Multilayered nanoconstructs for targeted delivery of drugs/siRNA to treat various cancers” 3rd International Conference on Materials Science and Engineering”. September 26-27, 2024 in Amsterdam, Netherlands